Caution with other centrally acting drugs. Avoid with alcohol. May potentiate the effect of certain antihypertensive agents. CYP3A4 inducers (e.g. carbamazepine) may increase clearance and lower blood levels. CYP3A4 inhibitors (e.g. ketoconazole, itraconazole) or CYP2D6 inhibitors (e.g. quinidine, fluoxetine, paroxetine) may inhibit elimination and increase blood levels.